Oxygen free radicals and cardiac reperfusion abnormalities.
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چکیده
منابع مشابه
Tutorials in Molecular and Cellular Biology Oxygen Free Radicals and Cardiac Reperfusion Abnormalities
Oxygen free radicals are highly reactive compounds causing peroxldation of lipids and proteins and are thought to play an important role in the pathogenesis of reperfusion abnormalities including myocardial stunning, irreversible injury, and reperfusion arrhythmias. Free radical accumulation has been measured in ischemic and reperfused myocardium directly using techniques such as electron param...
متن کاملActivation of cardiac vagal afferents in ischemia and reperfusion. Prostaglandins versus oxygen-derived free radicals.
Myocardial ischemia and reperfusion can evoke excitation of cardiac vagal nerve endings and activation of a cardiogenic depressor reflex (Bezold-Jarisch effect). We postulate that oxygen-derived free radicals, which are known to be produced during prolonged ischemia and reperfusion, contribute to this afferent excitation. We recorded activity from 47 chemosensitive vagal afferent fibers in 31 r...
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We have examined the pathophysiological role of readmission of oxygen (and hence production of oxygen-derived free radicals) in the initiation of reperfusion-induced arrhythmias by separating, on a temporal basis, readmission flow from readmission of oxygen. Isolated rat hearts (n = 12/group) were subjected to 10 minutes of regional ischemia and 10 minutes of reperfusion. In controls reperfused...
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established, the mechanism by which /?-carotene exerts a protective function against cancer remains unknown. However, there are several lines of evidence which suggest that the generation of reactive oxygen species may play an important role in the development of cancer [14]. The present work emphasizes that attention should be extended from /?-carotene to lycopene and other carotenoids. Lycope...
متن کاملBiochemistry of Oxygen and Its Free Radicals
Thrombolytic treatment in acute myocardial infarction achieves coronary patency in most patients.' Mortality in groups treated early after the onset of symptoms is significantly reduced,' but left ventricular function does not always improve.5 Myocardial necrosis during the period of vessel occlusion is partly responsible for the irreversible ventricular impairment that occurs even when the ves...
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ژورنال
عنوان ژورنال: Hypertension
سال: 1992
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.20.1.118